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Regional Anaesthesia:
M. L. Horta, L. C. L. Morejon, A. W. da Cruz, G. R. dos Santos, L. C. Welling, L. Terhorst, R. C. Costa, and R. U. Z. Alam
Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus
Br. J. Anaesth. 2006; 96: 796-800 [Abstract] [Full text] [PDF]
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[Read E-letter] Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morp
Marilise Galea   (14 June 2006)

Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morp 14 June 2006
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Marilise Galea,
SpR Anaesthesia and Intensive Care
St Peter's Hospital, Chertsey

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Re: Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morp

I read with interest the study by Horta and colleagues(1) in which they compared the prophylactic effect of droperidol, alizapride, propofol, and promethazine on spinal morphine-induced pruritus. Another group of drugs which have been found to be useful in this setting but notincluded in this study are 5-hydroxytryptamine subtype 3 (5-HT3) receptor antagonists such as ondansetron and dolasetron.

One of the postulated mechanisms of intrathecal opioid-induced pruritus is a direct excitatory effect of the opioid on the dorsal horn. High concentrations of 5-HT3 receptors have been located in the dorsal part of the spinal cord especially in the superficial layers of the dorsal horn, and in the nucleus of the spinal tract of the trigeminal nucleus, in animal studies(2). This indicates that opioids might cause pruritus by activating central 5-HT3. There are few studies on the effectiveness of 5- HT3 antagonists reported, and these have provided conflicting results. A study by Iatrou et al(3) showed a decreased incidence and severity of pruritus with the use of ondansetron and dolasetron in patients undergoing urological, orthopaedic or vascular surgery using intrathecal morphine. A similar result was obtained by Charuluxananan et al(4). On the other hand, a recent study by Sarvela et al(5) did not show any reduction in pruritus with ondansetron in patients undergoing elective caesarean section with intrathecal morphine and intravenous fentanyl. Also, most of the studies have compared the efficacy of a 5-HT3 receptor antagonist with a placebo and not to other drugs. It would be interesting to compare the efficacy of a 5-HT3 receptor antagonist such as ondansetron to the rest of the drugs.

References

1. Horta ML, Morejon LCL, da Cruz AW, dos Santos GR, Welling LC, Terhorst L, Costa RC, Alam RUZ. Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine- induced pruritus. Br J Anaesth 2006; 96: 796-800

2. Borgeat A, Stirnemann HR. Ondansetron is effective to treat spinal or epidural morphine-induced pruritus. Anaesthesiology 1999; 90: 432-6

3. Iatrou CA, Dragoumanis CK, Vogiatzaki TD, Vretzakis GI, Simopoulos CE, Dimitriou VK. Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double-blind, placebo -controlled study. Anaesth Analg 2005; 101: 1516-20

4. Charuluxananan S, Somboonviboon W, Kyokong O, Nimcharoendee K. Ondansetron for the treatment of intrathecal morphine-induced pruritus after caesarean delivery. Reg Anesth Pain Med 2000; 25: 535-9

5. Sarvela PJ, Halonen PM, Soikkeli AI, Kainu JP, Korttila KT. Ondasetron and tropisteron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective caesarean section. Acta Anaesthesiol Scand 2006; 50: 239-44

Conflict of Interest:

None declared