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BJA Advance Access published online on November 9, 2006
British Journal of Anaesthesia, doi:10.1093/bja/ael307
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted August 14, 2006

Laboratory Investigation

I.V. infusion of a drag-reducing polymer extracted from aloe vera prolonged survival time in a rat model of acute myocardial ischaemia{dagger}

T. Sakai 1, B. M. Repko 2, B. P. Griffith 3, J. H. Waters 4, and M. V. Kameneva 5 *

1 Department of Anesthesiology, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
2 Department of Radiology, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA
3 Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
4 Department of Anesthesiology, Magee-Women's Hospital of the University of Pittsburgh Medical Center and Medical Director, University of Pittsburgh Perioperative Blood Management Program, University of Pittsburgh, Pittsburgh, PA, USA
5 Department of surgery and Bioengineering, University of Pittsburgh, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

* To whom correspondence should be addressed.
M. V. Kameneva, E-mail: kamenevamv{at}upmc.edu


  Abstract

Background. I.V. infusion of drag-reducing polymers (DRPs) has been shown to improve survival time in animals subjected to haemorrhagic shock. We hypothesized that DRPs might prolong survival time in rats following acute myocardial ischaemia (AMI).

Methods. Sixteen adult male rats were anaesthetized and mechanically ventilated. An i.v. infusion of either Dextran-40 2.5% (Control, n=8) or Dextran-40 2.5% containing 50 µg ml-1 of an aloe vera-based DRP (DRP, n=8) was initiated at 3.5 ml h-1. The left anterior descending coronary artery was ligated. Blood pressure, skin-tissue perfusion, and heart rate were monitored and arterial blood samples were analysed.

Results. The mortality at 60 min following coronary ligation was 0% in the DRP group vs 50% in the control group (P=0.025). DRP-treated animals maintained higher mean arterial pressure [60.9 (5.1) vs 47.5 (5.1) mm Hg, P=0.004] and tissue perfusion [4.2 (3.4) vs 1.2 (0.5) TPU, P=0.029]. The DRP group trended towards better acid-base status with base excess [-5.0 (1.7) vs -8.1 (5.1) mmol litre-1, P=0.083] and pH [7.42 (0.07) vs 7.35 (0.02), P=0.03].

Conclusions. Administration of nanomolar concentrations of aloe vera-based DRP prolonged survival time in animals with AMI. DRPs may offer a novel method to treat organ/tissue hypoperfusion.

Keywords: drag-reducing polymer, aloe vera; heart, cardiac ischaemia; microcirculation; rat.
{dagger}Presented at the Annual Meeting of the American Society of Anesthesiologists, New Orleans, Louisiana, October 22-25, 2005.
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