Skip Navigation



BJA Advance Access published online on August 1, 2006
British Journal of Anaesthesia, doi:10.1093/bja/ael211
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
97/4/499    most recent
ael211v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yew, W. S.
Right arrow Articles by Pal, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yew, W. S.
Right arrow Articles by Pal, S. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted June 21, 2006

Clinical Investigation

Correlation of microalbuminuria and outcome in patients with extensive burns{dagger}

W. S. Yew 1 and S. K. Pal 2 *

1 Clinical Fellow, Department of Anaesthesia, St Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, Essex CM1 7ET, UK
2 Professor, Department of Anaesthesia, St Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, Essex CM1 7ET, UK

* To whom correspondence should be addressed.
S. K. Pal, E-mail: Sandipal{at}aol.com


  Abstract

Background. Microalbuminuria, often referred to as the urinary albumin-creatinine ratio (ACR), is thought to be a reflection of increased capillary permeability associated with the systemic inflammatory response syndrome, and has been found to be predictive of outcome in several studies. Therefore, we explored the usefulness of ACR as a predictor of mortality, and whether there was a correlation between ACR and PaO2/FIO2 ratios in patients with extensive burns.

Methods. A retrospective observational study was carried out on all patients with extensive burns admitted to the burns intensive care unit. All adult patients with burns of at least 40%, or those with significant inhalational injury, were included. Exclusion criteria were paediatric patients or those with non-thermal processes such as Stevens-Johnson's syndrome. ACR was measured daily, and data including PaO2/FIO2 ratios were collected. The outcome studied was mortality.

Results. A total of 21 patients were studied, of which there were 7 mortalities. Data were analysed using SPSS Ver11. Patient characteristic data between survivors and mortalities were similar. We did not find any correlation between trends of ACR with PaO2/FIO2 ratios. However, in non-survivors, there were two peaks in ACR, an early peak at days 8-9, and a later peak at day 32, whereas concentrations remained stable in survivors.

Conclusion. We conclude that while ACR is useful as a predictor of mortality and that mean ACR of more than 20 mg mmol-1 is associated with poorer outcome, changes in ACR do not reflect changes in the patients' immediate clinical conditions.

Keywords: complications, burns; complications, mortality; microalbuminuria.
{dagger}Abstract presented at the Annual Scientific Meeting of the Association of Burns and Reconstructive Anaesthetists in Liverpool, October 15, 2004.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
T. H. Nguyen, T. Hoppe-Tichy, H. K. Geiss, A. C. Rastall, S. Swoboda, J. Schmidt, and M. A. Weigand
Factors influencing caspofungin plasma concentrations in patients of a surgical intensive care unit
J. Antimicrob. Chemother., July 1, 2007; 60(1): 100 - 106.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.