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BJA Advance Access published online on March 10, 2006
British Journal of Anaesthesia, doi:10.1093/bja/ael046
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted January 6, 2006

Laboratory Investigation

Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors

J.-H. Sou 1, M.-H. Chan 2, and H.-H. Chen 2 *

1 Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, R.O.C.; Department of Health, Yuli Hospital, Executive Yuan, Hualien, Taiwan, R.O.C.
2 Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, R.O.C.

* To whom correspondence should be addressed.
H.-H. Chen, E-mail: hwei{at}mail.tcu.edu.tw


  Abstract

Background. Group I metabotropic glutamate receptors (mGluRs) have been reported to regulate N-methyl-D-aspartate (NMDA) receptor function in various brain regions. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate NMDA antagonists such as PCP and MK-801-induced behavioural responses. In the present study, the role of group I mGluRs on ketamine- and propofol-induced general anaesthesia was examined.

Methods. Mice were pretreated with various doses of the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG), selective mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), mGluR1 antagonist 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) and mGluR5 antagonist MPEP followed by administration of ketamine (120 mg kg-1) or propofol (140 mg kg-1) to induce anaesthesia. The duration of loss of righting reflex was recorded.

Results. DHPG and CHPG antagonized and MPEP potentiated ketamine-induced anaesthesia in a dose-dependent manner. CPCCOEt was in effective. However, propofol-induced anaesthesia was not affected after manipulating mGluR1 and mGluR5 receptors.

Conclusions. mGluR5 receptors play an important role in modulation of anaesthesia induced by ketamine, but not propofol.

Keywords: anaesthesia; anaesthetics i.v., ketamine; anaesthetics i.v., propofol; receptors; mGluR1; receptors, mGluR5.
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