BJA Advance Access published online on January 16, 2006
British Journal of Anaesthesia, doi:10.1093/bja/ael003
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1 Department of Anaesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
* To whom correspondence should be addressed. Background. Bladder discomfort related to intraoperative catheterization of urinary bladder is a distressing symptom and more so in patients awakening from anaesthesia. These symptoms are similar to symptoms of overactive bladder. Muscarinic receptor antagonists have been reported to be effective in the treatment of overactive bladder. This study was therefore undertaken to evaluate the efficacy of oxybutynin and tolterodine in preventing catheter related bladder discomfort. Methods. Two hundred and thirty-four consecutive adult patients, ASA I and II, of either sex, undergoing elective percutaneous nephrolithotomy surgery requiring urinary bladder catheterization were randomized into three equal groups of 78 each. Group C (control) received placebo, Group O (oxybutynin) received oxybutynin 5 mg and Group T (tolterodine) received tolterodine 2 mg orally 1 h before surgery. After induction of anaesthesia patients were catheterized with a 16 Fr Foley's catheter and the balloon was inflated with 10 ml distilled water. The bladder discomfort was assessed at 0, 1, 2 and 6 h after patient's arrival in the post-anaesthesia care unit. Severity of bladder discomfort was graded as mild, moderate and severe. Results. Incidence of bladder discomfort observed in the control group was higher, i.e. 58% (45/78), compared with oxybutynin and tolterodine groups where it was 35% (28/78) and 33% (26/78), respectively (P<0.05). Significant reduction in the severity of bladder discomfort was also observed after oxybutynin and tolterodine therapy compared with control (P<0.05). Conclusion. Pretreatment with either oxybutynin or tolterodine reduces the incidence and severity of catheter related bladder discomfort.
Accepted December 13, 2005
Clinical Investigation
Comparison of efficacy of oxybutynin and tolterodine for prevention of catheter related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study
A. Agarwal 1 *,
S. Dhiraaj 1,
V. Singhal 1,
R. Kapoor 2,
and
M. Tandon 1
2 Department of Surgical Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
A. Agarwal, E-mail: aagarwal{at}sgpgi.ac.in
Abstract 
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