Skip Navigation



BJA Advance Access published online on January 16, 2006
British Journal of Anaesthesia, doi:10.1093/bja/ael002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
96/3/310    most recent
ael002v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Plaschke, K.
Right arrow Articles by Bardenheuer, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Plaschke, K.
Right arrow Articles by Bardenheuer, H. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted December 13, 2005

Clinical Investigation

Adenosine-induced cardiac arrest and EEG changes in patients with thoracic aorta endovascular repair

K. Plaschke 1 *, D. Boeckler 2, H. Schumacher 2, E. Martin 1, and H. J. Bardenheuer 1

1 Clinic of Anaesthesiology, University of Heidelberg, Germany
2 Department of Vascular and Endovascular Surgery, University of Heidelberg, Germany

* To whom correspondence should be addressed.
K. Plaschke, E-mail: konstanze.plaschke{at}med.uni-heidelberg.de


  Abstract

Background. We studied haemodynamic and metabolic variables, and cerebral function after cardiac arrest induced by high dose of adenosine in patients undergoing thoracic aorta endovascular repair.

Methods. Arterial blood pressure, blood gas values and EEG were recorded continuously in 15 patients undergoing anaesthesia (isoflurane) for endovascular thoracic aorta repair. Cardiac arrest was induced by different doses of adenosine (Adrekar®, Sanofi-Synthelabo, Berlin, Germany; 0.4-1.8 mg kg-1 body weight). Serum concentrations of neurone-specific enolase (NSE) were determined before and after stent graft implantation. Neurological function was assessed before and after surgery.

Results. After adenosine, the heart beat stopped immediately for 18-58 s in close relation to the adenosine dose. EEG power was significantly reduced to -57%, but reached normal values within 5 min after cardiac arrest. In particular, the fast alpha- and beta-EEG-frequencies sensitively reflected patients' EEG activity during the procedure. No intraoperative increases in NSE concentrations, and no neurological dysfunctions after surgery, were observed.

Conclusion. After adenosine-induced cardiac arrest, changes in haemodynamic variables and EEG power spectra reversed completely within 1 and 5 min, respectively, without persistent brain dysfunction after stent graft implantation.

Keywords: brain, electroencephalography; heart, cardiac arrest, adenosine; surgery, vascular.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.