Skip Navigation



BJA Advance Access published online on November 29, 2005
British Journal of Anaesthesia, doi:10.1093/bja/aei285
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
96/1/88    most recent
aei285v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kakinohana, M.
Right arrow Articles by Sugahara, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kakinohana, M.
Right arrow Articles by Sugahara, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Accepted October 10, 2005

Laboratory Investigation

Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats{dagger}

M. Kakinohana 1 *, S. Nakamura 1, T. Fuchigami 1, K. J. Davison 2, M. Marsala 3, and K. Sugahara 1

1 Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
2 Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA
3 Department of Anesthesiology, University of California, San Diego, CA, USA

* To whom correspondence should be addressed.
M. Kakinohana, E-mail: mnb-shk{at}ryukyu.ne.jp


  Abstract

Background. Intrathecal (IT) morphine given after a short interval of aortic occlusion in a rodent model induced transient spastic paraparesis via opioid receptor-predicted actions in spinal cord. To determine the role(s) of spinal opioid receptor subtypes we investigated whether IT administration of various selective opioid receptor agonists can induce paraparesis following a short period of spinal cord ischaemia in rats.

Methods. In Sprague-Dawley rats implanted with an IT catheter, spinal cord ischaemia was induced for 6 min using an intraaortic balloon. Mu ([D-Ala2, N-Me Phe4, Gly-ol5] enkephalin), kappa (U50488H) or delta ([D-Pen2,5] enkephalin) selective agonists were injected intrathecally 30 min after reperfusion. A separate group of animals was used to investigate the dose-response effect on this motor dysfunction. For this purpose, three doses of mu, kappa, or delta agonists were injected intrathecally after ischaemia. After IT injection, recovery of motor function was assessed periodically using the motor deficit index (0=complete recovery; 6=complete paraplegia).

Results. IT administration of mu and delta but not kappa agonists produced dose-dependent effects in the induction of spastic paraparesis. In addition, this spasticity induced by IT mu and delta agonists was reversed completely by IT naloxone and naltrindole, respectively.

Conclusion. These results suggest that the effect of various opioids on motor function after a short period of spinal cord ischaemia depends upon individual opioid receptor subtypes.

Keywords: agonists, DAMGO, DPDPE, U50488H; complications, paraparesis; complications, spinal cord ischaemia; receptors, opioid.
{dagger}This work has been attributed mainly to Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
C. Lentschener, B. Dousset, M. Zuber, and Y. Ozier
Central Sensory-Motor Deficit After Uneventful Single-Dose Spinal Morphine Administration in a Patient with Preexisting Migraine Headaches
Anesth. Analg., November 1, 2009; 109(5): 1688 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. D. Sanders and M. Maze
Translational Research: Addressing Problems Facing the Anesthesiologist
Anesth. Analg., October 1, 2007; 105(4): 899 - 901.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
M. Smith and R. P. Mahajan
Clinical neuroscience: relevance to current practice
Br. J. Anaesth., July 1, 2007; 99(1): 1 - 3.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.