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BJA Advance Access published online on September 16, 2005
British Journal of Anaesthesia, doi:10.1093/bja/aei241
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oxfordjournals.org
Accepted August 23, 2005

Clinical Investigation

Tracheal intubating conditions and apnoea time after small-dose succinylcholine are not modified by the choice of induction agent

M. I. El-Orbany 1*, N. J. Joseph 2, and M. R. Salem 1

1 Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL, USA; Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, USA
2 Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL, USA

* To whom correspondence should be addressed.
M. I. El-Orbany, E-mail: mohammad.el-orbany-md{at}advocatehealth.com


  Abstract

Background. In a randomized, double-blind clinical trial, we studied the effect of different i.v. induction drugs on tracheal intubation conditions and apnoea time after small-dose (0.6 mg kg-1) succinylcholine used to facilitate orotracheal intubation at an urban, university-affiliated community medical centre.

Methods. One hundred and seventy-five ASA I and II adult patients scheduled to undergo surgical procedures requiring general anaesthesia and tracheal intubation were allocated to one of five groups according to i.v. anaesthetic induction drug used. General anaesthesia was induced by i.v. administration of lidocaine 30 mg and propofol 2.5 mg kg-1 (Group 1), thiopental 5 mg kg-1 (Group 2), lidocaine 30 mg and thiopental 5 mg kg-1 (Group 3), etomidate 0.3 mg kg-1 (Group 4), or lidocaine 30 mg and etomidate 0.3 mg kg-1 (Group 5). After loss of consciousness, succinylcholine 0.6 mg kg-1 was given i.v. followed by direct laryngoscopy and tracheal intubation after 60 s. Measurements included intubation conditions recorded during laryngoscopy 60 s after succinylcholine administration, and apnoea time.

Results. Overall, clinically acceptable intubation conditions were met in 168 out of the 175 patients studied (96%). They were met in 35/35 patients in Group 1, 33/35 patients in Group 2, 34/35 patients in Group 3, 33/35 patients in Group 4, and 33/35 patients in Group 5. Mean (SD) apnoea time was 4.0 (0.4), 4.2 (0.3), 4.2 (0.6), 4.1 (0.2) and 4.1 (0.2) min respectively in Groups 1-5. There were no differences in the intubation conditions or apnoea times between the groups.

Conclusions. The use of succinylcholine 0.6 mg kg-1 produced the same favourable intubation conditions and a short apnoea time regardless of the induction drug used.

Keywords: intubation, endotracheal; neuromuscular block, succinylcholine; small-dose succinylcholine.
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Tracheal intubating conditions and apnoea time after small-dose succinylcholine are not modified by
Jameel Ahmed Khan
British Journal of Anaesthesia, 9 Nov 2005 [Full text]

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