Skip Navigation



BJA Advance Access published online on September 2, 2005
British Journal of Anaesthesia, doi:10.1093/bja/aei229
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/5/701    most recent
aei229v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Buczkowski, P. W.
Right arrow Articles by Thompson, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buczkowski, P. W.
Right arrow Articles by Thompson, J. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oxfordjournals.org
Accepted August 1, 2005

Laboratory Investigation

Effects of helium on high frequency jet ventilation in model of airway stenosis

P. W. Buczkowski 1*, F. N. Fombon 1, W. C. Russell 1, and J. P. Thompson 2

1 Department of Anaesthesia, Critical Care and Pain Management, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, UK
2 Department of Cardiovascular Sciences, Clinical Division of Anaesthesia, Critical Care & Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK

* To whom correspondence should be addressed.
P. W. Buczkowski, E-mail: piotrbuczkowski{at}hotmail.com


  Abstract

Background. The addition of helium to the inspired gas may facilitate ventilation in the presence of clinically evident upper airway obstruction. However, there are no data on the effects of using a helium-oxygen mixture during high frequency jet ventilation (HFJV) in upper airway obstruction.

Methods. HFJV at a frequency of 150 min-1 (driving pressure 2 bar, inspiratory time 30%) was applied to a trachea-lung model to simulate ventilation through varying degrees of fixed laryngotracheal stenosis (2.5-8.5 mm). HFJV was delivered from above, through and below the level of stenosis to simulate supraglottic, transglottic and infraglottic administration. Measurements of distal tracheal pressures were repeated for each route at steady state for each stenosis diameter using both 100% oxygen and helium-oxygen (50% oxygen, 50% helium). The output of the ventilator was measured during operation on oxygen and helium-oxygen.

Results. Peak, mean and end-expiratory pressures were greater during simulated supraglottic HFJV than during transglottic and infraglottic HFJV, and pressures increased markedly as the diameter of the stenosis decreased for all routes of ventilation (P<0.001). Generated pressures during HFJV using helium-oxygen and 100% oxygen were very similar overall, although reductions in pressures were observed during ventilation with helium-oxygen via the transglottic and transtracheal routes at stenosis diameters <4 mm (P<0.05). However, HFJV with the helium-oxygen mixture increased the delivered gas volumes by ~18%.

Conclusions. Using 50% helium-oxygen during HFJV in the presence of airway stenosis allows an 18% increase in minute volume at generated airway pressures which are the same as or lower than those when using 100% oxygen.

Keywords: airway, obstruction; gases non-anaesthetic; model, gas dynamics; ventilation, high frequency jet.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
P. W. Buczkowski, F. N. Fombon, E. S. Lin, W. C. Russell, and J. P. Thompson
Air entrainment during high-frequency jet ventilation in a model of upper tracheal stenosis
Br. J. Anaesth., December 1, 2007; 99(6): 891 - 897.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. J. G. and R. J. J.
Modelling: a core technique in anaesthesia and critical care research.
Br. J. Anaesth., November 1, 2006; 97(5): 589 - 592.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.