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BJA Advance Access published online on November 5, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aei025
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Accepted October 14, 2004

Clinical Investigation

Randomized controlled trial of effects of the airflow through the upper respiratory tract of intubated brain-injured patients on brain temperature and selective brain cooling

P. J. D. Andrews 1*, B. Harris 1, and G. D. Murray 2

1 Department of Anaesthesia, Intensive Care and Pain Management, University of Edinburgh, UK
2 Division of Community Health Sciences (Medical Statistics), University of Edinburgh, UK

* To whom correspondence should be addressed.
P. J. D. Andrews, E-mail: p.andrews{at}ed.ac.uk


  Abstract

Background. Pyrexia is common after brain injury; it is generally believed to affect outcome adversely and the usual clinical methods of reducing temperature are not effective. The normal physiological mechanisms of brain cooling are heat loss from the upper airways and through the skull, and these can produce selective brain cooling.

Methods. Air at room temperature and humidity was continuously administered to 15 brain-injured, intubated and mechanically ventilated patients via a sponge-tipped oxygen catheter in each nostril at a combined rate of 115 ml kg-1 min-1. Brain temperature was measured using a pressure-temperature Camino catheter which is designed to site the thermistor 1 cm into the parenchyma in the frontal lobe. Oesophageal temperature was measured using an oesophageal stethoscope with a thermistor. After establishing baseline for 30 min, patients were randomized to receive airflow or no airflow for 6 h and then crossed over for a further 6 h.

Results. Airflow replicating normal resting minute volume did not produce clinically relevant or statistically significant reductions in brain temperature [0.13 (SD 0.55)°C; 95% CI, 0.43-0.17°C]. However, we serendipitously found some evidence of selective brain cooling via the skull, but this needs further substantiation.

Conclusions. A flow of humidified air at room temperature through the upper respiratory tracts of intubated brain-injured patients did not produce clinically relevant or statistically significant reductions in brain temperature measured in the frontal lobe.

Keywords: brain, direct brain cooling; brain, injury; brain, selective brain cooling; complications, head injury; complications, subarachnoid haemorrhage.
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