Skip Navigation



BJA Advance Access published online on October 1, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh271
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/6/833    most recent
aeh271v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Vagts, D. A.
Right arrow Articles by Nöldge-Schomburg, G. F. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vagts, D. A.
Right arrow Articles by Nöldge-Schomburg, G. F. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Accepted July 14, 2004

Laboratory Investigation

Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs{dagger}

D. A. Vagts 1*, K. Hecker 2, T. Iber 1, J. P. Roesner 1, A. Spee 1, B. Otto 2, R. Rossaint 2, and G. F. E. Nöldge-Schomburg 1

1 Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universität Rostock, Schillingallee 35, D-18055 Rostock, Germany
2 Klinik für Anästhesiologie, RWTH Aachen, Pauwelsstrasse 30, D-52072 Aachen, Germany

* To whom correspondence should be addressed. E-mail: dierk.vagts{at}medizin.uni-rostock.de.


  Abstract

Background. Xenon is a narcotic gas that might be able to replace volatile anaesthetics or nitrous oxide due to its favourable pharmacological properties, such as providing haemodynamic stability. Intestinal oxygenation is affected by most volatile anaesthetics as a result of cardiodepressive effects. Reducing oxygenation of the gut might be a factor leading to perioperative organ dysfunction. This animal study was designed to assess the effects of xenon on intestinal oxygenation.

Methods. After ethical approval, 24 anaesthetized, acutely instrumented pigs were randomly assigned to three groups: nine animals received xenon anaesthesia with inspiratory concentrations of 0, 20, 50 and 65% in addition to their basic i.v. anaesthesia, nine animals served as a study control group, and five animals were used to assess model stability. Measurement of systemic and regional haemodynamic and oxygenation parameters was made 30 min after changing the xenon concentration.

Results. Xenon elicited dose-dependent systemic haemodynamic changes: heart rate and cardiac output decreased by 30%, while mean arterial pressure was stable. Superior mesenteric artery blood flow was lower in the xenon group. Vascular resistance of the superior mesenteric artery increased. The small intestinal oxygen supply decreased with increasing xenon concentration; the mucosal tissue oxygen partial pressure decreased but did not reach hypoxic (<5 mm Hg) values. Serosal tissue oxygen partial pressure was maintained.

Conclusions. Xenon, in addition to basic i.v. anaesthesia, elicited a decrease in cardiac output and maintained mean arterial pressure. Intestinal oxygenation was maintained, although regional macrohaemodynamic perfusion decreased. Xenon does not impair intestinal oxygenation under physiological conditions.

Keywords: anaesthetics volatile, xenon; gastrointestinal tract, mucosal perfusion; model, pig.

{dagger}Presented in part at the 49th Annual Meeting of the German Society of Anesthesiology and Intensive Care Medicine, Nuernberg, Germany, June 22, 2002.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Lab AnimHome page
R. C E Francis, M. S Reyle-Hahn, C. Hohne, A. Klein, I. Theruvath, B. Donaubauer, T. Busch, and W. Boemke
The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs
Lab Anim, July 1, 2008; 42(3): 338 - 349.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.