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BJA Advance Access published online on September 17, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh269
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Accepted August 6, 2004

Case Report

Fulminant neuroleptic malignant syndrome after perioperative withdrawal of antiParkinsonian medication

M. Stotz 1*, D. Thümmler 2, M. Schürch 3, J.-C. Renggli 2, A. Urwyler 1, and H. Pargger 4

1 Department of Anaesthesia, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland
2 Department of Surgery, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland
3 Department of Anaesthesia, Kantonsspital Aarau, CH-5001 Aarau, Switzerland
4 Division of Operative Critical Care, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland

* To whom correspondence should be addressed. E-mail: Stotzm{at}hotmail.com.


  Abstract

Neuroleptic malignant syndrome is a rare complication when using neuroleptic drugs. We report the case of a patient with severe Parkinson's disease who developed neuroleptic malignant syndrome after withdrawal of his antiParkinsonian medication for elective coronary artery bypass grafting. Sodium dantrolene may be a therapeutic option in severe cases.

Keywords: complications, neuroleptic malignant syndrome; complications, Parkinson's disease; neuromuscular relaxant, sodium dantrolene; pharmacology, inhibitors, levodopa-benserazide; tolcapone.
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