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BJA Advance Access published online on July 26, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh227
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Review Article

Perioperative systemic haemostatic agents

A. M. Mahdy 1 N. R. Webster 1*

1 Academic Unit of Anaesthesia and Intensive Care, University of Aberdeen, Aberdeen, UK

* To whom correspondence should be addressed. E-mail: n.r.Webster{at}abdn.ac.uk.


  Abstract

Skilful surgery combined with blood-saving methods and careful management of blood coagulation will all help reduce unnecessary blood loss and transfusion requirements. Excessive surgical bleeding causes hypovolaemia, haemodynamic instability, anaemia and reduced oxygen delivery to tissues, with a subsequent increase in postoperative morbidity and mortality. The role of anaesthetists in managing surgical blood loss has increased greatly in the last decade. Position of the patient during surgery and the provision of a hypotensive anaesthetic regimen were once considered the most important contributions of the anaesthetist to decreasing blood loss. Now, several pharmacological haemostatic agents are being used by anaesthetists as blood-saving agents. After a brief discussion of the physiology of haemostasis, this article will review the evidence for the role of such agents in reducing perioperative blood loss and transfusion requirements.

Keywords: blood, factor VIIa; blood, haemostasis; blood, loss; polypeptides, aprotinin.
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E-letters:

Read all E-letters

New Concept in Coagulation Theory.
Wilson Thomas
British Journal of Anaesthesia, 2 Mar 2005 [Full text]
Topical perioperative haemostatic agents
John W Watt, et al.
British Journal of Anaesthesia, 19 Apr 2005 [Full text]

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