BJA Advance Access published online on June 25, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh191
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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1 Clinic for Anaesthesiology and Intensive Care Medicine, Friedrich-Schiller University of Jena, Erlanger Allee 103, D-07747 Jena, Germany
* To whom correspondence should be addressed. E-mail: cwsm.schummer{at}gmx.de.
Background. The classic increase in P wave size, known as ‘P-atriale’, is a widely accepted criterion for determination of proper positioning of central venous catheter tips. Recent transoesophageal echocardiography (TOE) studies did not confirm intra-atrial position despite advancing the central venous catheter further than indicated by ECG guidance. We postulate that the pericardial reflection rather than the entry into the right atrium corresponds to the ECG changes. In order to test our hypothesis we sought to determine the anatomical substrate for the electrical changes in an animal study. Subsequently, a modified version of the study was undertaken in man and is also reported. Methods. In six juvenile pigs the left external jugular vein and right carotid artery were cannulated. A triple-lumen central venous catheter was positioned by ECGguidance using a Seldinger wire as an exploring electrode. The venous and arterial catheters were suture fixed 2 cm beyond the onset of an increase in P wave size. The corresponding anatomical catheter tip position was determined by open exploration of the vessels and the heart. Subsequently the catheter tip position (during advancement) of a pulmonary artery catheter and the corresponding electrical ECG changes were examined in 10 patients during open chest cardiac surgery. Results. All catheters--arterial and venous, in animals and humans--revealed an increase in size of the P wave as well as the QRS complex. All venous catheters were positioned in the superior vena cava, beyond the pericardial reflection but outside the right atrium. All arterial catheters were positioned in the ascending aorta thus also beyond the pericardial reflection. Conclusions. The start of an increase in P wave size does not correspond with the entrance of the right atrium. The anatomic equivalent for the electrophysiological changes of the ECG is the pericardial reflection. ECG guidance is unable to distinguish between venous and arterial catheter position.
Clinical Investigation
Central venous catheters--the inability of ‘intra-atrial ECG’ to prove adequate positioning
2 Department of Cardiothoracic and Vascular Surgery, Friedrich-Schiller University of Jena, Bachstrasse 18, Germany
3 Institute for Experimental Animals, University of Jena, Dornburger Strasse 23, D-07740 Jena, Germany
4 Biomagnetic Center, Friedrich-Schiller University of Jena, University of Applied Sciences, Erlanger Allee 101, D-07747 Jena, Germany; Klinik fur Innere Medizin III, Friedrich-Schiller University of Jena, University of Applied Sciences, Erlanger Allee 101, D-07747 Jena, Germany
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