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BJA Advance Access published online on May 28, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh184
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Accepted March 21, 2004

Clinical Investigation

Effect of prostaglandin E1 on inflammatory responses and gas exchange in patients undergoing surgery for oesophageal cancer

K. Nakazawa 1*, Y. Narumi 1, S. Ishikawa 1, K. Yokoyama 1, T. Nishikage 2, K. Nagai 2, T. Kawano 2, K. Makita 1

1 Department of Anaesthesiology and Critical Care Medicine, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan
2 Department of Oesophagogastric Surgery, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan

* To whom correspondence should be addressed. E-mail: nakazawa.mane{at}tmd.ac.jp.


  Abstract

Background. Oesophageal surgery causes morbidity and mortality from respiratory complications. We tested the possibility that prostaglandin E1 (PGE1) could reduce inflammatory cytokine responses and improve gas exchange after oesophagectomy.

Methods. We randomized 14 patients into two groups. One group received PGE1 20 ng kg-1 min-1 i.v. during anaesthesia (PGE1 group) and the other group did not (control group). Anaesthesia was maintained with sevoflurane and epidural anaesthesia. During oesophagectomy, ventilation of one lung was carried out with a double-lumen bronchial tube. The patients were extubated on or after the first postoperative day. Blood samples were taken at induction of anaesthesia, at the end of thoracotomy, at the end of the operation, 2 h after surgery and on the first day after surgery.

Results. The groups were similar for ASA physical status, age, FEV1%, operation time, duration of thoracotomy, intraoperative fluid volume and blood loss. The arterial blood gas and arterial pressure during surgery were also similar in the PGE1 and control groups. However, the PaO2/FIO2 ratio on the first day after surgery was significantly greater in the PGE1 group compared with the control group. Serum concentrations of IL-6 and IL-8 increased after surgery in both groups. IL-6 was significantly less in the PGE1 group at the end of the operation and 2 h after the operation.

Conclusions. Intraoperative PGE1 reduced IL-6 production in patients undergoing oesophagectomy and oxygenation was better in the postoperative period.

Keywords: Keywords: blood, oxygenation; hormones, prostaglandins; polypeptides, cytokines, interleukins; surgery, transthoracic oesophagectomy


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