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BJA Advance Access published online on March 19, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh128
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Accepted December 5, 2003

Short Communication

Effects of propofol on respiratory mechanic and lung histology in normal rats

A. Peratoner 1, C. S. Nascimento 2, M. C. E. Santana 2, R. A. Cadete 3, E. M. Negri 4, A. Gullo 1, P. R. M. Rocco 2, W. A. Zin 3*

1 Istituto Polidisciplinare di Anestesia, Rianimazione e Terapia Antalgica, Università di Trieste, Trieste, Italy
2 Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Ilha do Fundão, 21949-900, Rio de Janeiro, Brazil
3 Laboratory of Respiration Physiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Ilha do Fundão, 21949-900, Rio de Janeiro, Brazil
4 LIM 59--Cellular Biology, A.C. Camargo Cancer Hospital, Department of Thoracic Medicine, São Paulo, Brazil

* To whom correspondence should be addressed. E-mail: wazin{at}biof.ufrj.br.


  Abstract

Background. Propofol is able to reduce airway resistance in lungs with previous airway constriction. The aim of this study was to evaluate the effects of propofol on respiratory mechanics in normal rats and to correlate these parameters with lung histology, to define the sites of action of propofol.

Methods. Sixteen Wistar rats were divided into two groups of eight animals. Rats were sedated (diazepam) and anaesthetized with pentobarbital sodium (C) or propofol (P), and paralysed. Respiratory system, lung, and chest wall resistive, elastic, and viscoelastic/inhomogeneous pressures were computed using the end-inflation occlusion method.

Results. Lung resistive pressure was smaller in group P (0.29 kPa (0.05)) than group C (0.37 kPa (0.04)) (P=0.007). The internal diameter of the central airways was greater in group P than C (P=0.01).

Conclusion. Propofol acts at the airway level decreasing respiratory system and lung impedances as a result of central airway dilation.

Keywords: Keywords: anaesthesia; anaesthetics i.v., propofol; lung, respiratory mechanics; lung, bronchus, contraction index


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