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BJA Advance Access published online on February 20, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh106
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
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Accepted December 9, 2003

Case Reports

Rocuronium for muscle relaxation in two children with Friedreich’s ataxia

H. J. Schmitt 1*, S. Wick 2, T. Münster 2

1 Department of Anaesthesiology, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany; Department of Anaesthesiology, Friedrich-Alexander Universität Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany
2 Department of Anaesthesiology, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

* To whom correspondence should be addressed. E-mail: hubert.schmitt{at}kfa.imed.uni-erlangen.de.


  Abstract

Friedreich’s ataxia is a rare hereditary neurodegenerative disease caused by a defect in the gene that encodes a mitochondrial protein called frataxin. We report the use of rocuronium 0.6 mg kg-1 in two adolescent girls with Friedreich’s ataxia undergoing propofol-sufentanil-oxygen-air anaesthesia for spinal surgery. Neuromuscular transmission was monitored using acceleromyography, and onset and recovery times were recorded. The clinical duration of rocuronium was comparable to that of children without neuromuscular disease (25% recovery T1=44 and 24 min for patients 1 and 2 respectively).

Keywords: Keywords: anaesthetic techniques, intravenous; complications, Friedreich’s ataxia; neuromuscular block, rocuronium


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