Skip Navigation



BJA Advance Access published online on January 22, 2004
British Journal of Anaesthesia, doi:10.1093/bja/aeh077
© 2004 by The Board of Management and Trustees of the British Journal of Anaesthesia
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
92/3/421    most recent
aeh077v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hecker, K. E.
Right arrow Articles by Rossaint, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hecker, K. E.
Right arrow Articles by Rossaint, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Accepted September 26, 2003

Short Communication

Minimum alveolar concentration (MAC) of xenon in intubated swine

K. E. Hecker 1*, N. Horn 1, J. H. Baumert 1, S. M. Reyle-Hahn 2, N. Heussen 3, R. Rossaint 1

1 Department of Anaesthesiology, Klinikum der RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany
2 Department of Anaesthesiology and Intensive Care, Waldkrankenhaus Berlin, Germany
3 Department of Medical Statistics, Klinikum der RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany

* To whom correspondence should be addressed. E-mail: klaus.hecker{at}post.rwth-aachen.de.


  Abstract

Background. The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MACXe.

Methods. The study was performed using ten swine (weight 27.8-35.4 kg) anaesthetized with halothane and Xe 0, 15, 30, 40, 50 and 65% in oxygen. With each Xe concentration, various concentrations of halothane were administered in a step-by-step design. For each combination, a supramaximal pain stimulus (claw clamp) was applied and the appearance of a withdrawal reaction was recorded. The MACXe with halothane was calculated using a logistic regression model.

Results. During stable ventilation, haemodynamics and temperature, MACXe value was determined as 119 vol. % (95% confidence limits 103-135).

Conclusion. MACXe in swine was calculated by extrapolation of a logistic regression model. Its theoretical value is 119 vol. %.

Br J Anaesth 2004

Keywords: Keywords: anaesthesia, closed circuit; anaesthetics volatile; pharmacology


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
E. I. Eger II, M. Tang, M. Liao, M. J. Laster, K. Solt, P. Flood, A. Jenkins, D. Raines, J. F. Hendrickx, S. L. Shafer, et al.
Inhaled Anesthetics Do Not Combine to Produce Synergistic Effects Regarding Minimum Alveolar Anesthetic Concentration in Rats
Anesth. Analg., August 1, 2008; 107(2): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. F. A. Hendrickx, E. I. Eger II, J. M. Sonner, and S. L. Shafer
Is Synergy the Rule? A Review of Anesthetic Interactions Producing Hypnosis and Immobility
Anesth. Analg., August 1, 2008; 107(2): 494 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, K. E. Hecker, M. Hein, M. Reyle-Hahn, N. A. Horn, and R. Rossaint
Effects of xenon anaesthesia on the circulatory response to hypoventilation
Br. J. Anaesth., August 1, 2005; 95(2): 166 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, K. E. Hecker, M. Hein, S. M. Reyle-Hahn, N. A. Horn, and R. Rossaint
Haemodynamic effects of haemorrhage during xenon anaesthesia in pigs
Br. J. Anaesth., June 1, 2005; 94(6): 727 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. Schwarzkopf, T. Schreiber, E. Gaser, N.-P. Preussler, L. Hueter, H. Schubert, H. Rek, and W. Karzai
The Effects of Xenon or Nitrous Oxide Supplementation on Systemic Oxygenation and Pulmonary Perfusion During One-Lung Ventilation in Pigs
Anesth. Analg., February 1, 2005; 100(2): 335 - 339.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
D. A. Vagts, K. Hecker, T. Iber, J. P. Roesner, A. Spee, B. Otto, R. Rossaint, and G. F. E. Noldge-Schomburg
Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs
Br. J. Anaesth., December 1, 2004; 93(6): 833 - 841.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.