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Hypothermia and cerebrovascular reactivity
Utrecht, The Netherlands
* E-mail: o.l.cremer@umcutrecht.nl
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Editor—Lavinio and colleagues1 have touched upon an important topic by suggesting that temperatures above 37°C may cause hyperaemic derangement of cerebrovascular reactivity in severely head-injured patients. However, one of the major limitations of their retrospective analysis lies in the fact that the effects of temperature could not be separated from any temporal changes that occurred in the brain after injury. Rewarming took place at a time when inflammatory responses in the brain presumably had evolved significantly compared with when the patients were cooled.2 Indeed,
Cambridge, UK Brescia, Italy
* E-mail: andrea.lavinio@gmail.com