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BJA Advance Access originally published online on July 24, 2007
British Journal of Anaesthesia 2007 99(4):518-521; doi:10.1093/bja/aem201
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis

O. Piazza1,*, E. Russo1, S. Cotena1, G. Esposito2 and R. Tufano1

1 Anestesia e Rianimazione, Università degli Studi di Napoli ‘Federico II’, via Pansini 5 (Ed 8), 80131 Napoli, Italy
2 Patologia Clinica, IRCCS Pascale, Napoli, Italy

* Corresponding author. E-mail: orpiazza{at}unina.it

Background: Sepsis-associated encephalopathy (SAE) is defined as a diffuse cerebral dysfunction induced by the systemic response to infection without any clinical or laboratory evidence of direct infectious involvement of the central nervous system. The astroglial protein S100B has been used as a marker of severity of brain injury and as a prognostic index in trauma patients and cardiac arrest survivors. We measured S100B serum levels in patients with severe sepsis to investigate if the severity of SAE correlated with an increase in S100B levels.

Methods: Twenty-one patients, with a diagnosis of severe sepsis, were included in this study. S100B levels were measured at intensive care unit (ICU) admission, 72 h and 7 days after admission. Their association with markers of brain dysfunction such as Glasgow coma scale (GCS), and EEG, and with sepsis-related organ failure assessment score (SOFA) and ICU mortality was investigated.

Results: Fourteen patients had elevated S100B levels. The levels did not correlate with GCS at admission, EEG pattern, or SOFA scores. Also, S100B levels did not differ between patients who recovered neurologically and those who did not (P = 0.62).

Conclusions: In severe sepsis, an increase in S100B does not allow the physicians to distinguish patients with severe impairment of consciousness from those with milder derangements or to prognosticate neurological recovery.

Keywords: brain, blood–brain barrier; brain, electroencephalography; complications, infections; complications, multiple organ dysfunction syndrome; complications, neurological


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This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J. K. Panni, M. K. Panni, O. Piazza, E. Russo, S. Cotena, G. Esposito, and R. Tufano
Changes in S100B levels rather than absolute values may be a better marker of severity of septic encephalopathy
Br. J. Anaesth., March 1, 2008; 100(3): 419 - 420.
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Changes in S100B levels rather than absolute values may be a better marker of severity of encephalop
Joana K. Panni, et al.
British Journal of Anaesthesia, 20 Nov 2007 [Full text]
Are changes in serum S100B a prognostic index in sepsis associated encephalopathy?
Ornella Piazza
British Journal of Anaesthesia, 11 Dec 2007 [Full text]

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