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BJA Advance Access originally published online on March 8, 2007
British Journal of Anaesthesia 2007 98(5):624-627; doi:10.1093/bja/aem057
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Reversal of rocuronium-induced (1.2 mg kg–1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg–1){dagger}

A. L. Molina1, H. D. de Boer2,*, M. Klimek1, M. Heeringa3 and J. Klein1

1 Department of Anaesthesiology, Erasmus University Medical Centre, Rotterdam, The Netherlands
2 Department of Anaesthesiology, Radboud University Medical Centre Nijmegen, Martini Hospital Groningen, The Netherlands
3 Global Clinical Development, NV Organon, Oss, The Netherlands

* Corresponding author: Department of Anaesthesiology, Martini Hospital Groningen, PO Box 30033, 9700 RM, Groningen, The Netherlands. E-mail: hd.de.boer{at}mzh.nl

Sugammadex is the first selective relaxant binding agent and reverses rocuronium-induced neuromuscular block. A case is reported in which a patient accidentally received a high dose of sugammadex (40 mg kg–1) to reverse a rocuronium-induced (1.2 mg kg–1) profound neuromuscular block. A fast and efficient recovery from profound neuromuscular block was achieved and no adverse events or other safety concerns were reported.

Keywords: neuromuscular block, rocuronium; neuromuscular relaxant, sugammadex; reversal agent

{dagger} Declaration of interest. This case report was part of a study supported by NV Organon, Oss, The Netherlands.


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