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British Journal of Anaesthesia 2007 98(5):557-559; doi:10.1093/bja/aem088
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Urotensin II: from osmoregulation in fish to cardiovascular regulation in man

The first 10% of the full text of this article appears below.

Urotensin II (U-II) is a cyclic peptide first isolated from the urophysis of the teleost fish Gillichthys mirabilis where it is involved in osmoregulation.1 The human isoform was identified in 1998,2 and 1 yr later its cognate Gq G-protein coupled receptor, UT (de-orphanized GPR14) was identified.3 Human U-II is composed of 11 amino acids and is cleaved from a larger precursor. An additional urotensin-related peptide has also been identified. Human UT is encoded on chromosome 17q25.3, is intronless, and is composed of 389 amino acids. There are several single nucleotide polymorphisms of both U-II and UT and their association with the range of cardiovascular disease phenotypes is largely undefined. The peptide and receptor show diverse distribution, including brain, respiratory system, heart, vasculature, and kidney. U-II is currently described . . . [Full Text of this Article]

D. G. Lambert

Department of Cardiovascular Science, Pharmacology and Therapeutics Group, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, LRI, Leicester, LE1 5WW, UK

E-mail: DGL3@le.ac.uk


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J. P. Williams, J. P. Thompson, S. P. Young, S. J. Gold, J. McDonald, D. J. Rowbotham, and D. G. Lambert
Nociceptin and urotensin-II concentrations in critically ill patients with sepsis
Br. J. Anaesth., June 1, 2008; 100(6): 810 - 814.
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