Skip Navigation


BJA Advance Access originally published online on October 17, 2006
British Journal of Anaesthesia 2006 97(6):777-782; doi:10.1093/bja/ael271
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
97/6/777    most recent
ael271v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Mekontso-Dessap, A.
Right arrow Articles by Teboul, J.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mekontso-Dessap, A.
Right arrow Articles by Teboul, J.-L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

B-type natriuretic peptide to assess haemodynamic status after cardiac surgery

A. Mekontso-Dessap1,*, L. Tual2, M. Kirsch2, G. D'Honneur2, D. Loisance2, L. Brochard1 and J.-L. Teboul3

1 Medical Intensive Care Unit, Université Paris XII, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique—Hôpitaux de Paris INSERM U 651, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France
2 Cardiac Surgery Intensive Care Unit, Université Paris XII, Centre Hospitalier Universitaire Henri Mondor, Assistance Publique—Hôpitaux de Paris INSERM U 651, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France
3 Medical Intensive Care Unit, Université Paris XI, Centre Hospitalier Universitaire de Bicêtre, Assistance Publique—Hôpitaux de Paris 78, rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France

*Corresponding author: Service de Réanimation Médicale, Centre Hospitalier Universitaire Henri Mondor, 51, avenue du Mal de Lattre de Tassigny; 94010 Créteil Cedex, France. E-mail: armand.dessap{at}creteil.inserm.fr

Background. B-type natriuretic peptide (BNP) is the most powerful hormonal marker of left ventricular dysfunction and could be considered as an indicator of ventricular preload. The aim of this prospective study was to compare the respective value of BNP and cardiac filling pressures to assess the response to volume load after cardiac surgery.

Methods. Thirty-seven mechanically ventilated patients suffering from acute circulatory failure immediately after cardiac surgery, and equipped with a pulmonary-artery catheter were included. All haemodynamic measurements were taken before and after volume expansion using 500 ml of 4% modified fluid gelatin.

Results. Fifteen patients were volume responders (CI increase≥15%) and 22 were non-responders. Right atrial pressure, pulmonary-artery occlusion pressure and BNP before volume loading were not significantly different between the responders and non-responders. BNP concentration before volume infusion significantly correlated to preoperative left ventricular ejection fraction, aortic cross-clamping time, serum creatinine, mean pulmonary arterial pressure and intensive care unit duration whereas no correlation was found with pulmonary-artery occlusion pressure or cardiac index.

Conclusion. BNP level after cardiac surgery was influenced by many perioperative variables, limiting its usefulness as an indicator of cardiac preload or a predictor of volume responsiveness in this population.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J. W. Sear and G. Howard-Alpe
Preoperative plasma BNP concentrations: do they improve our care of high-risk non-cardiac surgical patients?
Br. J. Anaesth., August 1, 2007; 99(2): 151 - 154.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.