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British Journal of Anaesthesia 2006 97(2):262-263; doi:10.1093/bja/ael163
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Can large volume N2O uptake alone explain the second gas effect?

*E-mail: jwseps@comcast.net

The first 10% of the full text of this article appears below.

Editor—Hendrickx and colleagues1 report that the second gas effect of N2O, increasing the rate of uptake of sevoflurane during induction of general anaesthesia, is not diminished even when the sevoflurane is started after an hour of saturation of the body with N2O. This conclusion resulted from demonstration that the ratio of expired to inspired sevoflurane was about 5% higher in the presence of N2O than with oxygen as the other inspired gas. This conflicts with theoretical analysis of the second gas effect, which should depend on mass transfer into the lung of an additional soluble agent such as sevoflurane.

This surprise finding casts suspicion on the analytical accuracy of the Datex analyser. The authors do not report tests of the possible interactions of the CO2 . . . [Full Text of this Article]

J. W. Severinghaus*

San Francisco, USA

J. F. A. Hendrickx1,*, R. Carette2, H. J. M. Lemmens1 and A. M. De Wolf3

1 Stanford, CA, USA
2 Aalst, Belgium
3 Chicago, IL, USA

*E-mail: jcnwahendrickx@yahoo.com


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