BJA Advance Access originally published online on May 2, 2006
British Journal of Anaesthesia 2006 96(6):727-731; doi:10.1093/bja/ael085
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Magnesium sulphate as a technique of hypotensive anaesthesia
1 Department of Anesthesiology and Intensive Care, Faculty of Medicine, Ain-shams University Cairo, Egypt
2 Department of Otorhinolaryngology, Faculty of Medicine, Ain-shams University Cairo, Egypt
*Corresponding author: 8 Moktar El Masry Street, El-Golf land Heliopolise, Cairo, Egypt. E-mail: nmelsharnouby{at}hotmail.com
Background. This randomized, double-blind, placebo-controlled study was designed to assess the effect of perioperatively administered i.v. magnesium sulphate as a technique of hypotensive anaesthesia.
Methods. Sixty patients (25 female) undergoing functional endoscopic sinus surgery were included in two parallel groups. The magnesium group received magnesium sulphate 40 mg kg–1 i.v. as a bolus before induction of anaesthesia and 15 mg kg–1 h–1 by continuous i.v. infusion during the operation. The same volume of isotonic solution was administered to the control group. Intraoperative bleeding was evaluated using a quality scale.
Results. In the magnesium group, there was a reduction in surgical time [68.1 (15.6) min vs 88.1 (10.7) min], although the anaesthetic time was 10 min longer and thus presuming a prolongation in anaesthetic emergence. There was a significant reduction of blood loss [165 (19) ml vs 257 (21) ml]. The anaesthetic requirements (fentanyl, vercuronium and sevoflurane), mean arterial blood pressure (P<0.005) and heart rate (P<0.005) were also significantly reduced.
Conclusion. Magnesium sulphate led to a reduction in arterial pressure, heart rate, blood loss and duration of surgery. Furthermore, magnesium infusion alters anaesthetic dose requirements and emergence time.
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