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British Journal of Anaesthesia 2006 96(3):289-291; doi:10.1093/bja/ael016
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

EDITORIAL

The remarkable memory effects of propofol

R. A. Veselis

New York, NY, USA

E-mail: veselisr@mskcc.org

The first 10% of the full text of this article appears below.

Not so long ago, the tried and true amnesic drug was diazepam, which was quickly replaced by midazolam when it became available. These drugs are often referred to as ‘prototypical benzodiazepines', and the prototypical effect of greatest interest is well described by Sebel.1 He recounts the ability to eat dinner and have a conversation after a somnolent dose of ‘a benzodiazepine’, with no recollection of any bit of that transatlantic dinner the next day. This remarkable ability to wipe out episodic memory has been put to sinister use in the case of Rohypnol (flunitrazepam), which now has the unfortunate label of a ‘prototypical date-rape’ drug.2 It is an amazing state of affairs when a person can behave in essentially a normal fashion, yet have no recollection of any action, even traumatic ones, during this time period. Now . . . [Full Text of this Article]


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 Br J AnaesthHome page
K. Girgirah, S. M. Kinsella, and R. A. Veselis
Propofol and memory.
Br. J. Anaesth., November 1, 2006; 97(5): 746 - 748.
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