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British Journal of Anaesthesia 2005 95(4):559; doi:10.1093/bja/aei595
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

CORRESPONDENCE

Hypoalbuminaemia and propofol pharmacokinetics

* E-mail: d-takiza@bf6.so-net.ne.jp

The first 10% of the full text of this article appears below.

Editor—Cavaliere and colleagues report that hypoalbuminaemia does not affect the accuracy of Diprifusor during sedation with propofol.1 They hypothesized that hypoalbuminaemia may affect the accuracy of target-controlled infusion (TCI) by introducing major deviations in propofol pharmacokinetics. Their results, however, failed to show significant differences in the accuracy of the Diprifusor between hypo- and normoalbuminaemic patients. A possible explanation for these results is that the effect of hypoalbuminaemia may be too small . . . [Full Text of this Article]

D. Takizawa*, E. Sato, N. Ito, Y. Ogino, H. Hiraoka and F. Goto

Maebashi, Japan

* E-mail: f.cavaliere@rm.unicatt.it

F. Cavaliere*, G. Conti, U. Moscato, F. Meo, M. A. Pennisi, R. Costa and R. Proietti

Rome, Italy


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