Skip Navigation


BJA Advance Access originally published online on June 24, 2005
British Journal of Anaesthesia 2005 95(3):349-354; doi:10.1093/bja/aei181
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/3/349    most recent
aei181v1
Right arrow E-Letters: Submit a response to the article
Right arrow E-letters: View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Barbara, J.
Right arrow Articles by Leynadier, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbara, J.
Right arrow Articles by Leynadier, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

Prevention of latex sensitization in guinea pigs by a bacterial and viral filter used in anaesthesia

J. Barbara1,2, M.-C. Santais2, D. A. Levy1, F. Ruff2,{dagger} and F. Leynadier1,*

1 Laboratoire Universitaire de Recherche en Immuno-Allergologie (LURIA), Centre d'Allergologie, Hôpital Tenon (AP-HP), 4 rue de la Chine, F-75970 Paris Cedex 20, France. 2 Laboratoire de Physiopathologie Respiratoire, Université Paris V, UFR Biomédicale, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France

* Corresponding author. E-mail: francisque.leynadier{at}tnn.ap-hop-paris.fr

Background. Preventing anaphylactic reactions as a result of natural rubber latex (NRL) proteins is an important concern in anaesthesia. The clinical relevance of a bacterial/viral filter (PallTM BB25) in preventing sensitization to NRL by inhalation was tested in guinea pigs.

Methods. Guinea pigs (n=8–10 in each group) were exposed to aerosolized NRL-contaminated cornstarch powder or to NRL in saline for 1 h every day for 2 weeks. The experiments were repeated with a PallTM BB25 filter placed over the aerosol system. Control groups were exposed to non-contaminated cornstarch or to saline alone. Three weeks after the last exposure, specific bronchial challenge was performed and thromboxane (Tx) B2 levels in bronchoalveolar lavage fluid were measured.

Results. After bronchial challenge, the animals exposed to NRL or NRL-contaminated cornstarch with the BB25 filter in place showed a level of bronchoconstriction (i.e. the variation of pulmonary insufflation pressure) not different from controls. Conversely, those exposed to NRL or NRL-contaminated cornstarch without the filter showed a higher level of bronchoconstriction (respectively, P<0.02 and P<0.001) than control. Elevated TxB2 levels were found in the lungs of the guinea pigs, which inhaled NRL or NRL-contaminated cornstarch in the absence of a filter. Animals treated with the filter showed comparable TxB2 levels with those of control.

Conclusion. The PallTM BB25 filter efficiently protected the guinea pigs from sensitization to NRL. This filter can be used as a complementary measure for avoidance of NRL contact during surgical procedures particularly if the mechanical ventilator apparatus contain NRL devices.

{dagger} Deceased.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


E-letters:

Read all E-letters

Preventing latex exposure during anaesthesia
ASHISH RAJKUMAR, et al.
British Journal of Anaesthesia, 19 Sep 2005 [Full text]

Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.