Skip Navigation


BJA Advance Access originally published online on June 10, 2005
British Journal of Anaesthesia 2005 95(2):212-215; doi:10.1093/bja/aei168
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/2/212    most recent
aei168v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fodale, V.
Right arrow Articles by Santamaria, L. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fodale, V.
Right arrow Articles by Santamaria, L. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

Tramadol does not modify the Bispectral Index during anaesthesia with sevoflurane and remifentanil

V. Fodale*, C. Praticò, M. Tescione, S. Tanania, T. Lucanto and L. B. Santamaria

Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, School of Medicine, Policlinico Universitario ‘G. Martino’, Messina, Italy

* Corresponding author: Department of Neuroscience, Psychiatric and Anesthesiological Sciences, Policlinico Universitario, via C. Valeria, 98125 Messina, Italy. E-mail: vfodale{at}unime.it

Background. The aim of this study was to investigate the effects of tramadol administered with ketorolac on the Bispectral Index (BIS) during anaesthesia with sevoflurane and remifentanil.

Methods. Forty-six adult patients, ASA I–III, scheduled for elective minor surgical procedures were studied. Patients were premedicated with remifentanil infusion 0.4 µg kg–1 min–1 and anaesthesia was induced 4–5 min later with propofol 1.5 mg kg–1 and maintained with air–oxygen ( 0.4), remifentanil 0.1–0.15 µg kg–1 min–1 and sevoflurane, adjusted to keep the BIS between 40 and 50. After 20 min of stable anaesthesia, the subjects were allocated randomly to receive i.v. tramadol 1.5 mg kg–1 and i.v. ketorolac 0.3 mg kg–1 (tramadol group) or saline (control group). BIS values, mean arterial pressure, heart rate and end-tidal carbon dioxide were recorded every 5 min for 20 min.

Results. Mean BIS values after tramadol administration were not significantly different from those recorded in patients receiving saline throughout the period of observation. There were no patients who presented explicit recall of events under anaesthesia. No significant changes in mean arterial pressure, heart rate and end-tidal carbon dioxide were noted after tramadol injection.

Conclusion. Tramadol, given with ketorolac to prevent postoperative pain, during anaesthesia maintained with sevoflurane and remifentanil at BIS between 40 and 50, does not modify the BIS value.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.