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BJA Advance Access originally published online on October 14, 2004
British Journal of Anaesthesia 2005 95(1):33-42; doi:10.1093/bja/aeh290
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2004. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

REVIEW ARTICLE

Allogeneic red blood cell transfusions: efficacy, risks, alternatives and indications

C. Madjdpour and D. R. Spahn*

Department of Anaesthesiology, University Hospital Lausanne, Switzerland

* Corresponding author: Department of Anaesthesiology, University Hospital Lausanne (CHUV), CH-1011 Lausanne, Switzerland. E-mail: donat.spahn{at}chuv.hospvd.ch

Careful assessment of risks and benefits has to precede each decision on allogeneic red blood cell (RBC) transfusion. Currently, a number of key issues in transfusion medicine are highly controversial, most importantly the influence of different transfusion thresholds on clinical outcome. The aim of this article is to review current evidence on blood transfusions, to highlight ‘hot topics’ with respect to efficacy, outcome and risks, and to provide the reader with transfusion guidelines. In addition, a brief synopsis of transfusion alternatives will be given. Based on up-to-date information of current evidence, together with clinical knowledge and experience, the physician will be able to make transfusion decisions that bear the lowest risk for the patient.


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