BJA Advance Access originally published online on March 11, 2005
British Journal of Anaesthesia 2005 94(6):821-824; doi:10.1093/bja/aei119
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Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results
rDepartment of Anaesthesiology and Reanimation, Medical Faculty, Inonu University, Malatya, Turkey
* Corresponding author: akoroglu{at}inonu.edu.tr
Background. We evaluated the sedative, haemodynamic and respiratory effects of dexmedetomidine and compared them with those of midazolam in children undergoing magnetic resonance imaging (MRI) procedures.
Methods. Eighty children aged between 1 and 7 yr were randomly allocated to receive sedation with either dexmedetomidine (group D, n=40) or midazolam (group M, n=40). The loading dose of the study drugs was administered for 10 min (dexmedetomidine 1 µg kg–1 or midazolam 0.2 mg kg–1) followed by continuous infusion (dexmedetomidine 0.5 µg kg–1 h–1 or midazolam 6 µg kg–1 min–1). Inadequate sedation was defined as difficulty in completing the procedure because of the child's movement during MRI. The children who were inadequately sedated were given a single dose of rescue midazolam and/or propofol intravenously. Mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (
) and ventilatory frequency (VF) were monitored and recorded during the study.
Results. The quality of MRI was significantly better and the rate of adequate sedation was higher in group D than in group M (P<0.001). In group D, the requirement for rescue drugs was lower and the onset of sedation time was shorter than in group M (P<0.001). MAP, HR and VF decreased from baseline during sedation in both groups (P<0.001).
Conclusions. Dexmedetomidine provided adequate sedation in most of the children aged 1–7 yr without haemodynamic or respiratory effects during MRI procedures.
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