BJA Advance Access originally published online on October 29, 2004
British Journal of Anaesthesia 2005 94(1):107-111; doi:10.1093/bja/aei008
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2004
Comparison of plain and hyperbaric solutions of ropivacaine for spinal anaesthesia
University Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK Present addresses: 1 Department of Anaesthesia, John Radcliffe Hospital, Oxford OX3 9DU, UK. 2 Department of Anaesthesia, Frimley Park Hospital, Camberley GU16 7UJ, UK
* Corresponding author. E-mail: j.a.w.wildsmith{at}dundee.ac.uk
Background. Preliminary work has shown that ropivacaine provides spinal anaesthesia of shorter duration than bupivacaine, and may be of particular use in the day-case setting. However, there are few data comparing the actions of plain and hyperbaric solutions of this drug.
Methods. Forty ASA grade I–II patients undergoing elective perineal surgery under spinal anaesthesia were randomized to receive 3 ml ropivacaine 5 mg ml–1, either in plain solution or with glucose 50 mg ml–1. The extent and duration of sensory and motor block, pulse rate, blood pressure, and time to mobilization were recorded.
Results. Two patients (one per group) were withdrawn because of total block failure. There were significant differences in median time to onset of sensory block at T10 (plain 10 min; hyperbaric 5 min; P<0.01), median maximum extent (plain T8; hyperbaric T4; P<0.05), and median duration of sensory block at T10 (plain 25 min; hyperbaric 115 min; P<0.001). However, median times to complete regression of both sensory (270 vs 240 min; P<0.05) and motor (180 vs 120 min; P<0.001) block were longer in the plain group. Patients therefore mobilized sooner in the hyperbaric group (218 [n=16] vs 286 min [n=17]; P<0.01). All the hyperbaric blocks were adequate for surgery, but three patients receiving plain ropivacaine required general anaesthesia.
Conclusion. Addition of glucose 50 mg ml–1 to ropivacaine 5 mg ml–1 increases the speed of onset, block reliability, duration of useful block for perineal surgery, and speed of recovery. Plain solutions are less reliable for surgery above a dermatomal level of L1.
Declaration of interest. Dr Fettes and Dr Luck have had salaries paid by AstraZeneca. Professor Wildsmith has also received consultancy payments from AstraZeneca. AstraZeneca provided the ropivacaine for the study.
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