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BJA Advance Access originally published online on May 14, 2004
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British Journal of Anaesthesia, 2004, Vol. 93, No. 1 140-148
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Genomics and the circulation

M. V. Podgoreanu* and D. A. Schwinn

Box 3094, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710 USA.

*Corresponding author. E-mail: Podgo001@mc.duke.edu

Keywords: cardiovascular system, genomics

The first 150 words of the full text of this article appear below.

From genetics to genomics

Between the elucidation of DNA sequence in 1953 and completion of the draft sequence of the human genome in 2001,62 108 the new discipline of genomics was born, studying the functions and interactions of all genes in a systematic fashion, including their interaction with environmental factors. Using large-scale experimental methodologies and statistical analyses, functional genomics aims to analyse the regulation of gene expression in response to changes in physiological parameters, whereas the goal of structural genomics is to determine the three-dimensional structures of proteins. The conceptual quantum leap from genetics to genomic medicine began with the identification of a variable stretch of DNA (i.e. a polymorphism) near the human ß-globin gene associated with the sickle-cell mutation,56 followed by the suggestion that the location of genes could be predicted in given kindreds by their genetic linkage to a variant,11 equivalent to gene mapping. The advent of positional cloning in the 1980s gave . . . [Full Text of this Article]

Genetic analysis of complex cardiovascular diseases

Linkage analysis
Association studies
Large-scale gene expression profiling in cardiovascular disease

Genomic approach to heart failure

Genomic approach to myocardial ischaemia and cardioprotection

Genomic approach to atherogenesis

Limitations of gene expression profiling

Genome–Proteome–Physiome/Cardiome–Phenome

Conclusion


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