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British Journal of Anaesthesia, 2004, Vol. 92, No. 2 277-279
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats

J. Gao*,1, B. X. Zeng1, L. J. Zhou2 and S. Y. Yuan1

1 Department of Anesthesiology, Union Hospital and 2 Department of Child and Adolescent Health and Maternal Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China

*Corresponding author. Email: gaoju_003@163.com

Background. To investigate the effects of propofol administration on acute lung injury in endotoxin-induced shock in rats.

Methods. Seventy-six male Wistar rats were randomly assigned to one of five groups: (i) saline control; (ii) endotoxin alone (receiving lipopolysaccharide (LPS) 8 mg kg–1 i.v.); (iii) pretreatment with propofol 1 h before LPS; (iv) simultaneous treatment with propofol and LPS; (v) post-treatment with propofol 1 h after LPS. During the 5 h after LPS injection, survival rates were recorded. Lung tissue was sampled to measure values of nitrite/nitrates (NO2–/NO3–) and tumour necrosis factor (TNF)-{alpha} in bronchoalveolar lavage (BAL) fluid, and wet-to-dry lung weight ratio, pulmonary permeability index, BAL protein and expression of inducible nitric oxide synthase (iNOS) and nitrotyrosine (NT).

Results. Compared with the endotoxaemic group, both the pre- and simultaneous treatment groups showed significantly improved 5 h survival rates, and attenuated endotoxin-induced increased BAL fluid NO2– /NO3– and TNF-{alpha}, iNOS mRNA and NT expression in lung tissue, and decreased pulmonary microvascular permeability. These beneficial effects were blunted in the post-treatment group.

Conclusions. These findings indicate that early administration of propofol may provide protective effects against endotoxin-induced acute lung injury.

Br J Anaesth 2004; 92: 277–9


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