Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kodaka, M.
Right arrow Articles by Miyao, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kodaka, M.
Right arrow Articles by Miyao, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2004, Vol. 92, No. 2 238-241
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Relation between fentanyl dose and predicted EC50 of propofol for laryngeal mask insertion

M. Kodaka*, Y. Okamoto, F. Handa, J. Kawasaki and H. Miyao

Department of Anesthesiology, Saitama Medical Center, Saitama Medical School, 1981, Tsujido-cho, Kamoda, Kawagoe, Saitama 350-8550, Japan

*Corresponding author. E-mail: kmkodaka@cb3.so-net.ne.jp
{dagger}LMA® is the property of Intavent Limited.

Background. This study sought to determine the effective concentration for 50% of the attempts to secure laryngeal mask insertion (predicted EC50LMA) of propofol using a target-controlled infusion (DiprifusorTM) and investigated whether fentanyl influenced these required concentrations, respiratory rate (RR) and bispectral index (BIS).

Methods. Sixty-four elective unpremedicated patients were randomly assigned to four groups (n = 16 for each group) and given saline (control) or fentanyl 0.5, 1 or 2 µg kg–1. Propofol target concentration was determined by a modification of Dixon’s up-and-down method. Laryngeal mask airway insertion was attempted without neuromuscular blocking drugs after equilibration had been established for >10 min. Movement was defined as presence of bucking or gross purposeful muscular movement within 1 min after insertion. EC50LMA values were obtained by calculating the mean of 16 patients in each group.

Results. Predicted EC50LMA of the control, fentanyl 0.5, 1 and 2 µg kg–1 groups were 3.25 (0.20), 2.06 (0.55), 1.69 (0.38) and 1.50 (0.54) µg ml–1 respectively; those of all fentanyl groups were significantly lower than that of control. RR was decreased in relation to the fentanyl dose up to 1 µg kg–1. BIS values after fentanyl 1 and 2 µg kg–1 were significantly greater than in the control and 0.5 µg kg–1 groups.

Conclusions. A fentanyl dose of 0.5 µg kg–1 is sufficient to decrease predicted EC50LMA with minimum respiratory depression and without a high BIS value.

Br J Anaesth 2004; 92: 238–41


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
S. Malviya, T. Voepel-Lewis, A. R. Tait, M. F. Watcha, S. Sadhasivam, and R. H. Friesen
Effect of Age and Sedative Agent on the Accuracy of Bispectral Index in Detecting Depth of Sedation in Children
Pediatrics, September 1, 2007; 120(3): e461 - e470.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. P. Wang, P. McLoughlin, M. J. Paech, I. Kurowski, and E. L. Brandon
Low and Moderate Remifentanil Infusion Rates Do Not Alter Target-Controlled Infusion Propofol Concentrations Necessary to Maintain Anesthesia as Assessed by Bispectral Index Monitoring
Anesth. Analg., February 1, 2007; 104(2): 325 - 331.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. A. Dahaba
Different Conditions That Could Result in the Bispectral Index Indicating an Incorrect Hypnotic State
Anesth. Analg., September 1, 2005; 101(3): 765 - 773.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.