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British Journal of Anaesthesia, 2004, Vol. 92, No. 1 67-70
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia


Clinical Investigations

Preoperative saline versus gelatin for hip fracture patients; a randomized trial of 396 patients

M. J. Parker*,1, R. Griffiths2 and A. Boyle3

1 Department of Orthopaedicsand 2 Department of Anaesthesia, Peterborough District Hospital, Thorpe Road, Peterborough PE3 6DA, UK. 3 Department of Emergency Medicine,Addenbrooke’s Hospital, Cambridge, UK

*Corresponding author. E-mail: mjparker@doctors.org.uk

Background. The aim of this study was to determine if the preoperative administration of 500 ml of a gelatin colloid solution intravenously before hip fracture surgery improves outcome, compared with a conventional i.v. fluid regime with a crystalloid solution.

Methods. Randomized, double blind, controlled trial of i.v. saline vs colloid for 396 patients having hip fracture surgery admitted to a district general hospital. Patients were followed up for 1 yr.

Results. There was no statistically significant difference between groups for mortality (30-day mortality 9/198 for saline group vs 19/198 for colloid group, 95% confidence intervals 0.21–1.02), length of hospital stay (22.5 days vs 17.3 days, 95% CI –10.78 to 0.38), or occurrence of postoperative complications.

Conclusions. The inclusion of 500 ml of colloid solution to the i.v. fluid regime before hip fracture surgery does not improve outcome.

Br J Anaesth 2004; 92: 67–70


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