Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Davidson, A. J.
Right arrow Articles by Czarnecki, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davidson, A. J.
Right arrow Articles by Czarnecki, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2004, Vol. 92, No. 1 14-17
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

The Bispectral Index in children: comparing isoflurane and halothane

A. J. Davidson*,1,2 and C. Czarnecki1

1 Department of Anaesthesia, Royal Children’s Hospital and 2 Department of Pharmacology,University of Melbourne, Melbourne, Australia

*Corresponding author: Department of Anaesthesia, Royal Children’s Hospital, Flemington Road, Parkville, 3052 Victoria, Australia. E-mail: andrew.davidson@rch.org.au

Background. The Bispectral Index (BIS) has been calibrated for several general anaesthetic agents including isoflurane. Halothane is still used in paediatric anaesthesia. Compared with other volatile anaesthetics, halothane has a different receptor affinity and differing effects on the EEG. There are limited data evaluating the BIS with halothane. We set out to compare the BIS using halothane and isoflurane at a clinically relevant equipotent concentration (1 MAC) and at a reproducible measure of anaesthetic effect (awakening).

Methods. Forty children aged between 2 and 15 yr were enrolled in a masked randomized trial—20 in each group. Anaesthesia was induced with sevoflurane or propofol. Either halothane or isoflurane were given to obtain an end-tidal concentration of 1 MAC for 15 min. The BIS was then recorded. The BIS was also recorded at awakening. Values (mean (SD)) were compared with a t test.

Results. At 1 MAC the BIS for halothane was significantly greater than isoflurane (56.5 (8.1) vs 35.9 (8.5), P<0.0001). At awakening there was no significant difference (BIS halothane; 81.1 (11.9), BIS isoflurane; 82.5 (16.4)). The difference in means at awakening was 1.4 (95% CI –8.2 to 11.1).

Conclusions. At equipotent concentrations of halothane and isoflurane BIS valves were significantly greater with halothane. At awakening the BIS values were equivalent for each agent. This finding is consistent with the BIS being more affected by the agent used at higher concentrations of anaesthetic. The BIS must be interpreted with caution when using halothane.

Br J Anaesth 2004; 92: 14–17


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Asian Cardiovasc. Thorac. Ann.Home page
M. M. Maddali, P. V. Matreja, and M. Zachariah
Bispectral Index-Monitored Anesthesia Technique for Transsternal Thymectomy
Asian Cardiovasc Thorac Ann, August 1, 2009; 17(4): 389 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
C. Yi and D. Jee
Influence of the anaesthetic depth on the inhibition of the oculocardiac reflex during sevoflurane anaesthesia for paediatric strabismus surgery
Br. J. Anaesth., August 1, 2008; 101(2): 234 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
O. Tirel, E. Wodey, R. Harris, J. Y. Bansard, C. Ecoffey, and L. Senhadji
Variation of bispectral index under TIVA with propofol in a paediatric population
Br. J. Anaesth., January 1, 2008; 100(1): 82 - 87.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
O. Tirel, E. Wodey, R. Harris, J. Y. Bansard, C. Ecoffey, and L. Senhadji
The impact of age on bispectral index values and EEG bispectrum during anaesthesia with desflurane and halothane in children
Br. J. Anaesth., April 1, 2006; 96(4): 480 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. S. Litman, J. M. McDonough, C. L. Marcus, A. R. Schwartz, and D. S. Ward
Upper airway collapsibility in anesthetized children.
Anesth. Analg., March 1, 2006; 102(3): 750 - 754.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. A. Dahaba
Different Conditions That Could Result in the Bispectral Index Indicating an Incorrect Hypnotic State
Anesth. Analg., September 1, 2005; 101(3): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. E. Fletcher, A. R. Hinn, C. M. Heard, L. S. Georges, E. B. Freid, A. Keifer, S. D. Brooks, A. G. Bailey, and R. D. Valley
The Effects of Isoflurane and Desflurane Titrated to a Bispectral Index of 60 on the Cortical Somatosensory Evoked Potential During Pediatric Scoliosis Surgery
Anesth. Analg., June 1, 2005; 100(6): 1797 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. B. Andropoulos, S. A. Stayer, L. K. Diaz, and C. Ramamoorthy
Neurological Monitoring for Congenital Heart Surgery
Anesth. Analg., November 1, 2004; 99(5): 1365 - 1375.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.