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British Journal of Anaesthesia, 2003, Vol. 91, No. 5 615-618
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Should perioperative management target oxygen delivery?

S. J. Mackenzie1

1 Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh EH16 5SA, UK E-mail: simon.mackenzie@luht.scot.nhs.uk

The first 150 words of the full text of this article appear below.

Several strategies have been proposed to improve outcome after surgery. One of these is the use of fluids and catecholamines to achieve ‘supra-normal’ oxygen delivery, an approach variously termed ‘goal directed therapy’, ‘pre-optimization’, and ‘haemodynamic optimization’. This attractive concept is the basis of the study by Stone and colleagues,1 published in this issue of the journal. In this placebo controlled trial, patients who were given dopexamine at a rate of 0.25 µg kg–1 min–1 during surgery and for 24 h thereafter had a significantly higher cardiac index than patients given placebo, but morbidity and mortality were unaffected. Fluid therapy was used to increase stroke volume, measured using an oesophageal Doppler, before commencing the dopexamine. Oxygen delivery was not measured but the authors’ estimate, that it would have been between 500 and 550 ml min–1 m2 in the placebo group and over 600 ml min–1 m2 in the dopexamine group, is . . . [Full Text of this Article]

Dopexamine

Oxygen delivery

Implications for clinical practice

Addressing the unanswered questions


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 Br J AnaesthHome page
P. Older, A. Hall, M. P. W. Grocott, E. Chaloner, M. G. Mythen, and S. J. Mackenzie
Should perioperative management target oxygen delivery?
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 Br J AnaesthHome page
P. J. M. Bayly and R. J. T. Wilson
Effect of adding dopexamine to intraoperative volume expansion in patients undergoing major elective abdominal surgery
Br. J. Anaesth., April 1, 2004; 92(4): 598 - 599.
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