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British Journal of Anaesthesia, 2003, Vol. 91, No. 4 507-513
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Accuracy of the ‘Paedfusor’ in children undergoing cardiac surgery or catheterization

A. Absalom*,1, D. Amutike1,4, A. Lal2, M. White3 and G. N. C. Kenny1

1 University Department of Anaesthesia, Glasgow Royal Infirmary, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, UK. 2 Golden Jubilee National Hospital, Beardmore Street, Clydebank, Glasgow G81 4HX, UK. 3 University of Amsterdam Medical Centre, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands 4 Present address: Deptartment of Anaesthesia, Good Hope Hospital, Rectory Road, Sutton Coldfield, West Midlands B75 7RR, UK

Corresponding author. Present address: Department of Anaesthesia, Norfolk & Norwich University Hospital, Colney Lane, Norwich, Norfolk NR4 7UY, UK. E-mail: anthony.absalom@nnuh.nhs.uk
{dagger}LMA® is the property of Intavent Limited.

Background. A prototype paediatric propofol target-controlled infusion (TCI) system, the ‘Paedfusor’ has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures.

Methods. Twenty-nine children aged 1–15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor.

Results. The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1% and 9.7%, respectively and the median value for wobble was 8.3%. These values are much better than those found with the adult ‘Diprifusor’ system.

Conclusion. The Paedfusor performance was found to be within the accepted limits for use as a TCI system.

Br J Anaesth 2003; 91; 507–13


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