Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Horta, M. L.
Right arrow Articles by Vianna, P. T. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horta, M. L.
Right arrow Articles by Vianna, P. T. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2003, Vol. 91, No. 2 287-289
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Effect of intravenous alizapride on spinal morphine-induced pruritus

M. L. Horta1,2 and P. T. G. Vianna3

1 Department of Anesthesiology, Santa Casa de Misericórdia de Pelotas, Brazil. 2 Department of Anesthesiology, Hospital Universitário São Francisco de Paula da UCPEL, Pelotas, RS, Brazil. 3 Department of Anesthesiology of the School of Medicine of Botucatu, UNESP, Botucatu, SP, Brazil

Corresponding author: Rua Anchieta 4043, 96015.420, Pelotas, RS, Brazil. E-mail: marciolhorta@uol.com.br

Background. This double-blind study was undertaken to determine whether alizapride inhibits spinal morphine-induced pruritus.

Methods. Eighty-four patients undergoing Caesarean section under spinal anaesthesia (100 mg of hyperbaric lidocaine 5% plus morphine 0.2 mg) were randomly allocated to one of two groups. Just after birth, alizapride—50 mg (alizapride group) or metoclopramide—10 mg (metoclopramide group) were injected i.v. Patients were assessed after surgery for pruritus (absent, mild, moderate or severe) or other untoward symptoms.

Results. In the metoclopramide group, pruritus was absent in 5 (12%) patients, mild in 23 (55%), moderate in 11 (26%), and severe in 3 (7%), while in the alizapride group, these incidences were, respectively, 5 (12%), 33 (79%), 4 (10%), and 0 (P=0.045, {chi}2-test). There was no difference in the incidence of side-effects, which were all minor.

Conclusions. Alizapride reduced the severity of morphine-induced pruritus.

Br J Anaesth 2003; 91: 287–9


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
M. L. Horta, L. C. L. Morejon, A. W. da Cruz, G. R. dos Santos, L. C. Welling, L. Terhorst, R. C. Costa, and R. U. Z. Alam
Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus
Br. J. Anaesth., June 1, 2006; 96(6): 796 - 800.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.