Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sherman, R.
Right arrow Articles by Mahajan, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sherman, R.
Right arrow Articles by Mahajan, R. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2003, Vol. 91, No. 2 273-275
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Effects of magnesium sulphate on cerebral haemodynamics in healthy volunteers: a transcranial Doppler study

R. Sherman1, P. Armory1, P. Moody2, T. Hope2 and R. P. Mahajan*,1

1 University Department of Anaesthesia and Intensive Care and 2 Department of Neurosurgery, University Hospital and City Hospital, Nottingham, UK

Corresponding author. E-mail: ravi.mahajan@nottingham.ac.uk

Background. Magnesium is increasingly being considered as a neuroprotective agent. We aimed to study its effects on middle cerebral artery blood flow velocity (Vmca), cerebral autoregulation and cerebral vascular reactivity to carbon dioxide (CRCO2) in healthy volunteers.

Methods. Fifteen healthy volunteers were recruited. Using transcranial Doppler ultrasonography, Vmca was recorded continuously. The strength of autoregulation was assessed by the transient hyperaemic response test, and the CRCO2 was measured by assessing changes in Vmca to the induced changes in end-tidal carbon dioxide. I.V. infusion of magnesium sulphate was then started (loading dose of 16 mmol followed by an infusion at the rate of 2.7 mmol h–1) for 45 min. The cerebral haemodynamic variables were measured again near the end of the infusion of magnesium sulphate.

Results. Total serum magnesium levels were doubled by the infusion regimen. However, there were no significant changes in Vmca, strength of autoregulation, or CRCO2. Five of the volunteers reported marked nausea and two developed significant hypotension during the loading dose.

Conclusions. Infusion of magnesium sulphate, in a dose that doubles its concentration in plasma, does not affect Vmca, strength of autoregulation or CRCO2 in healthy volunteers. However, it can be associated with nausea and hypotension.

Br J Anaesth 2003; 91: 273–5


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 StrokeHome page
A. G. Euser and M. J. Cipolla
Magnesium Sulfate for the Treatment of Eclampsia: A Brief Review
Stroke, April 1, 2009; 40(4): 1169 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. G. Euser, L. Bullinger, and M. J. Cipolla
Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats
Exp Physiol, February 1, 2008; 93(2): 254 - 261.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.