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British Journal of Anaesthesia, 2003, Vol. 90, No. 6 725-727
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

IV. Do genes influence outcome from anaesthesia?

B. P. Sweeney1

1 Poole and Royal Bournemouth Hospitals, Department of Anaesthesia, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, Dorset BH7 7DW, UK E-mail: bpsween@aol.com

The first 150 words of the full text of this article appear below.

The last decade has seen an improved understanding of hepatic, xenobiotic metabolizing enzymes and how they may be affected by environmental influences, both natural and synthetic. These include pollutants such as solvents and petrochemicals, and enzyme inhibitors such as flavanoids in citrus fruits.1 Among these environmental factors, both alcohol and tobacco play an important role in determining the degree of liver enzyme induction, which determines the rate of metabolism of some medications, including volatile anaesthetic agents, thus influencing outcome from anaesthesia.2

Since the dawn of the biotechnology era, culminating in the successful unravelling of the human genome, it has become increasingly apparent that subtle inter-individual genetic differences underlie differing responses to both illness, and to pharmacological challenges. Indeed, the last decade has seen the emergence of a new cottage industry, based upon the latest techniques of DNA sequencing, whose main aim is to discover genetic polymorphisms, which hold the key . . . [Full Text of this Article]


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 Br J AnaesthHome page
J. Viby-Mogensen and B. Sweeney
Genes and outcome from anaesthesia
Br. J. Anaesth., November 1, 2003; 91(5): 755 - 756.
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