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British Journal of Anaesthesia, 2003, Vol. 90, No. 3 267-269
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial I

Sedating patients undergoing mechanical ventilation in the intensive care unit—winds of change?

K.-L. Kong1 and J. F. Bion2

1 Department of Anaesthesia, City Hospital, Dudley Road, Birmingham, B18 7QH, UK 2 University Department of Anaesthesia and Intensive Care Medicine, N5 Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

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The majority of mechanically ventilated patients in the intensive care unit (ICU) require sedation to reduce anxiety, encourage sleep and to increase tolerance to tracheal tubes and the ventilator. Sedative and analgesic drugs are amongst the most commonly prescribed medications in the ICU.1 The choice of agent and the way in which they are used varies widely between and within ICUs. In a survey of 164 ICUs in the US,2 18 different sedative agents were used, the commonest of which were the opiates and benzodiazepines. A more recent study3 revealed substantial differences in the clinical use of drugs for sedation and analgesia in the western European countries surveyed.

 These differences in clinical practice can have an important impact on patient outcome and cost of care: excessively deep . . . [Full Text of this Article]


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