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British Journal of Anaesthesia, 2003, Vol. 90, No. 2 212-220
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigations

Effects of epidural anaesthesia on intestinal oxygenation in pigs

D. A. Vagts*,1,4, T. Iber1,4, B. Szabo2, J. Haberstroh3, K. Reising1, M. Puccini1,4, K. Geiger1 and G. F. E. Nöldge-Schomburg1,4

1 Anaesthesiologische Universitätsklinik Freiburg, Hugstetter Strasse 55, D-79106 Freiburg im Breisgau, Germany. 2 Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Hermann-Herder-Strasse 5, D-79104 Freiburg im Breisgau, Germany. 3 Chirurgische Forschung, Chirurgische Universitätsklinik Freiburg, Hugstetter Strasse 55, D-79106 Freiburg im Breisgau, Germany. 4 Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universität Rostock, Schillingallee 35, D-18055 Rostock, Germany

Corresponding author: Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universität Rostock, Schillingallee 35, D-18055 Rostock, Germany
{dagger}Results were presented in part at the First International Symposium on Problems of the Gastrointestinal Tract in Anaesthesia, the Perioperative Period, and Intensive Care, Würzburg, Germany, October 1–3, 1998.

Background. Perioperative intestinal hypoperfusion is a major contributing factor leading to organ dysfunction. It can be caused by stress as a result of surgical manipulation or hypoxia. Additionally, anaesthesia can affect intestinal oxygenation. This animal study was designed to assess the effects of reduced regional sympathetic nervous activity induced by thoracic epidural anaesthesia on intestinal oxygenation.

Methods. After ethical approval, 16 anaesthetized and acutely instrumented pigs were randomly assigned to two groups (epidural anaesthesia alone vs epidural anaesthesia plus volume loading). The epidural anaesthesia aimed for a T5–T12 block. Measurements were at baseline and after 1 and 2 h.

Results. Epidural anaesthesia was associated with a decrease in mean arterial blood pressure and pronounced mesenteric vasodilatation. Mesenteric blood flow did not change. Intestinal oxygen uptake, mucosal tissue oxygen partial pressure and tissue carbon dioxide partial pressure remained unchanged.

Conclusions. Despite marked systemic hypotension, epidural anaesthesia did not affect intestinal oxygenation. There was no benefit obtained from volume loading.

Br J Anaesth 2003; 90: 212–20


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