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British Journal of Anaesthesia, 2003, Vol. 90, No. 2 148-154
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study

A. Lassnigg*,1, A. Punz2, R. Barker1, P. Keznickl1, N. Manhart2, E. Roth2 and M. Hiesmayr1

1 Department of Cardiothoracic Anaesthesia and Intensive Care Medicine and 2 Department of Surgical Research, University Hospital of Vienna, Waehringer Guertel 18–20, A-1090 Wien, Austria

Corresponding author. E-mail: andrea.lassnigg@univie.ac.at

Background. I.V. infusions of vitamin E emulsion (all-rac-{alpha}-tocopherol) may reduce ischaemia–reperfusion injury after elective cardiac surgery.

Methods. Forty patients participated in a prospective, double-blind, placebo-controlled, randomized trial, receiving either placebo or four doses (270 mg each) of all-rac-{alpha}-tocopherol between 16 h before and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C, malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of clinical outcome.

Results. Infusion of vitamin E caused normalization of vitamin E plasma concentrations during and after surgery, but had no effect on the early increase in malondialdehyde concentration or the decreases in antioxidative capacity and the water-soluble antioxidant vitamin C.

Conclusions. Normalization of plasma vitamin E concentrations with parenteral vitamin E emulsion does not affect biochemical markers of myocardial injury and does not affect clinical outcome after cardiac surgery.

Br J Anaesth 2003; 90: 148–54


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