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British Journal of Anaesthesia, 2003, Vol. 90, No. 2 115-121
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial I

Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis

M. C. Reade*,1 and J. D. Young1

1 Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary,Woodstock Road, Oxford OX2 6HE, UK

*Corresponding author: Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK, E-mail: michael.reade@anaesthetics.oxford.ac.uk

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Clinical studies investigating the pathogenesis of septic shock are fraught with problems. The focus of infection, the time between septic insult and presentation, and the varying treatments work together to produce a heterogeneous group of patients. There are ethical obstacles to observational studies on critically ill patients unable to give consent, as well as practical problems in obtaining specimens at a consistent time point in a rapidly evolving disease process. Compounding these problems, true septic shock is a relatively rare disease. In contrast, laboratory studies using cell cultures or rodent models are limited only by the available finance and expertise. As a result, the bulk of the literature investigating the pathogenesis of septic shock uses rodent models, or isolated or cultured cells. Therapeutic advances based on this research may well promise new hope for owners of rats requiring intensive care, but there is increasing evidence that human sepsis may be . . . [Full Text of this Article]

Acknowledgement


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