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British Journal of Anaesthesia, 2003, Vol. 90, No. 1 88-90
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Nitrous oxide decreases shivering threshold in rabbits less than isoflurane

M. Imamura1, T. Matsukawa*,1, M. Ozaki2, D. I. Sessler3, T. Nishiyama4, K. Okuyama1 and T. Kumazawa1

1 Yamanashi Medical University, Yamanishi, Japan. 2 Tokyo Women’s Medical University, Tokyo, Japan. 3 University of Louisville, Louisville, Kentucky, USA and Ludwig Boltzmann Institute, University of Vienna, Vienna, Austria. 4 Institute of Medical Science, University of Tokyo, Tokyo, Japan Department of Anaesthesia, Yamanashi Medical University, Yamanashi 409-3898, Japan. E-mail: takashim@res.yamanashi-med.ac.jp

Background. Comparable minimum alveolar concentration (MAC) fractions of volatile anaesthetics produce similar thermoregulatory impairment. Nitrous oxide, however, decreases the vasoconstriction threshold less than sevoflurane or isoflurane. We tested the hypothesis that nitrous oxide also decreases shivering threshold less than isoflurane alone or in combination.

Methods. Twenty-four rabbits were assigned randomly to one of three 0.3 MAC anaesthetic regimens: (i) nitrous oxide 69%; (ii) nitrous oxide 35% and isoflurane 0.3%; or (iii) isoflurane 0.6%. Body temperature was lowered by perfusing 10°C water through a U-shaped thermode positioned in the colon. Shivering was evaluated by inspection.

Results. The rabbits anaesthetized with nitrous oxide alone shivered at 37.0 (0.5)°C (P<0.01 vs other groups). In those given the nitrous oxide and isoflurane combination, the shivering threshold was 36.4 (0.5)°C and that in the isoflurane group was 35.9 (0.4)°C.

Conclusion. This study indicates that nitrous oxide reduces the shivering threshold less than isoflurane.

Br J Anaesth 2003; 90: 88–90


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