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British Journal of Anaesthesia, 2002, Vol. 89, No. 6 934-939
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Correspondence

In vivo effect of haemodilution with saline on coagulation

P. Innerhofer1, D. Fries1, A. Klingler1, W. Streif1, K. F. J. Ng2, C. C. K. Lam2 and L. C. Chan2

1 Innsbruck, Austria and 2 Hong Kong, China

The first 150 words of the full text of this article appear below.

Editor—As the influence of i.v. fluids on the coagulation system is of importance and also sustains the discussion on optimal fluid therapy, we would like to comment on the results reported by Ng and colleagues1 and the suggestions presented in the accompanying editorial.2 The study design chosen by Ng and colleagues1 to investigate coagulation and haemodilution might eliminate the influence of tissue trauma provoked by surgery, but is not ‘without the effect of any confounding variables’.2

First, the ratio of blood withdrawn:replacement with normal saline was 1:2, which suggests that the haemodiluted patients were hypovolaemic rather than haemodiluted. Second, all study subjects were patients with malignant disease, who are known to exhibit some state of hypercoagulability because of their underlying disease. Third, the shortening of the reaction time (r-time) by 30% and the coagulation time (k-time) by 36–45% was statistically different from the controls, but they also showed prolongation of . . . [Full Text of this Article]


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T. G. Ruttmann, P. Innerhofer, D. Fries, A. Klingler, and W. Streif
The effect of haemodilution on coagulation
Br. J. Anaesth., June 1, 2003; 90(6): 809 - 810.
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