Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rousseau, G. F.
Right arrow Articles by Swart, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rousseau, G. F.
Right arrow Articles by Swart, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 89, No. 6 846-848
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Plasma lidocaine concentrations following insertion of 2% lidocaine gel into the uterine cavity after uterine balloon thermal ablation

G. F. Rousseau*,1, M. Oram2, J. Barrington3, M. Priston4 and M. Swart2

1 Department of Anaesthesia, North Devon District Hospital, Barnstaple EX31 4JB, UK. 2 Department of Anaesthesia and Intensive Care and 3 Department of Obstetrics and Gynaecology, Torbay Hospital, Torquay TQ2 7AA, UK. 4 Pharmacy Department, Derriford Hospital, Plymouth PL6 8DH, UK guy.rousseau@virgin.net

Background. Uterine balloon thermal ablation is used to treat menorrhagia. We thought that intrauterine application of 2% lidocaine gel could reduce postoperative pain after this procedure. Before using this technique we wished to establish how much lidocaine is absorbed systemically from the uterine cavity after thermal ablation.

Methods. Ten ASA I–II patients (age 38–50 yr) underwent uterine balloon thermal ablation under general anaesthesia. They each had 11 ml of 2% lidocaine gel (InstillagelTM) inserted into the uterine cavity at the end of the procedure. Blood samples were taken at 5, 15, 30 and 60 min after insertion and lidocaine concentrations were measured using high-performance liquid chromatography.

Results. Mean (range) plasma lidocaine concentrations at 5, 15, 30 and 60 min were 40.3 (0–221.9), 66.3 (0–271.9), 64.9 (0–208) and 75 (0–212) ng ml–1, respectively.

Conclusion. There was minimal systemic absorption of lidocaine from the uterus following uterine balloon thermal ablation. Measured concentrations were well below the toxic plasma concentration for lidocaine (8–10 µg ml–1).

Br J Anaesth 2002; 89: 846–8


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.