Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fournier, R.
Right arrow Articles by Gamulin, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fournier, R.
Right arrow Articles by Gamulin, Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 89, No. 4 562-566
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Epinephrine and clonidine do not improve intrathecal sufentanil analgesia after total hip replacement{dagger}

R. Fournier*, E. Van Gessel, A. Weber and Z. Gamulin

Department of Anaesthesiology, University Hospital of Geneva, CH-1211 Geneva 14, Switzerland*Corresponding author: Département d’Anesthésiologie, Hôpital Cantonal Universitaire, CH-11 Genève 14, Switzerland

{dagger} Presented in part at the Annual Meeting of the American Society of Anesthesiology, San Francisco, October 2000.

Background. We compared analgesia after intrathecal sufentanil alone, sufentanil with epinephrine 200 µg and sufentanil with clonidine 30 µg in patients after total hip replacement, the endpoints being onset and duration of action.

Methods. We performed a randomized double-blind study of 45 patients for elective total hip arthroplasty using continuous spinal anaesthesia. As soon as a pain score higher than 3 on a 10 cm visual analogue scale was reported, sufentanil 7.5 µg alone, sufentanil 7.5 µg + epinephrine 200 µg or sufentanil 7.5 µg + clonidine 30 µg in 2 ml normal saline was given intrathecally. Pain scores, rescue analgesia (diclofenac and morphine) and adverse effects (respiratory depression, postoperative nausea and vomiting, itching) were observed for 24 h after surgery.

Results. Time to a pain score of <3 [6 (SD 1) vs 6 (1) vs 5 (1) min], time to the lowest pain score [7 (2) vs 8 (2) vs 8 (2) min] and time to the first dose of systemic analgesic for a pain score >3 [281 (36) vs 288 (23) vs 305 (30) min] were similar in all three groups. Adverse effects and analgesic requirements during the first 24 h were also similar.

Conclusion. After total hip replacement, all three analgesic regimens gave good analgesia with comparable onset and duration of action, and minor adverse effects.

Br J Anaesth 2002; 89: 562–6


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.